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2

抑制剂 & 化合物

7

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T36923	CXCR2-IN-2 CXCR2-IN-2
	CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC50=5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively). CXCR2-IN-2 displays ~730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-α induced CD11b expression with an IC50 of 0.04 μM[1]. CXCR2-IN-2 (compound 68) (1-10 mg/kg; p.o.; twice daily for 3 days) dose-dependently reduces neutrophil infiltration in vivo in ra...
T36443	(R,R)-CXCR2-IN-2 (R,R)-CXCR2-IN-2
	(R,R)-CXCR2-IN-2, diastereoisomer of CXCR2-IN-2 (compound 68), is a brain penetrant CXCR2 antagonist with a pIC50 of 9 and 6.8 in the Tango assay and d in the HWB Gro-α induced CD11b expression assay, respectively[1]. [1]. Lu H, et al. Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists. J Med Chem. 2018;61(6):2518-2532.

化合物

Cat.No: T36923

Synonym: CXCR2-IN-2

(R,R)-CXCR2-IN-2

Cat.No: T36443

Synonym: (R,R)-CXCR2-IN-2

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00006	GRO beta/CXCL2 Protein, Human, Recombinant GROb,MIP-2a,CINC-2a,GRO β/CXCL2,M...	Human	E. coli
	GRO beta/CXCL2 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 7.9 kDa and the accession number is A0A024RDD9.
TMPY-00009	GRO beta/CXCL2 Protein, Rat, Recombinant chemokine (C-X-C motif) ligand 2,GRO β/CXC...	Rat	E. coli
	GRO beta/CXCL2 Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 7.6 kDa and the accession number is A6KKD4.
TMPJ-00011	CXCL2 Protein, Mouse, Recombinant Gro-beta,GRO β,GROB,mela...	Mouse	E. coli
	C-X-C motif chemokine 2 (CXCL2,MIP-2) belongs to the intercrine alpha (chemokine CxC) family. It was originally identified as a heparin-binding protein secreted from a murine macrophage cell line in response to endotoxin stimulation. The expression of mouse MIP-2 is stimulated by endotoxin. The mouse MIP-2 shares approximately 63% aa sequence identity with murine KC, another mouse alpha chemokine, which is induced by PDGF. It has been suggested that mouse KC and MIP-2 are the homologs of the hum...
TMPY-04789	GRO beta/CXCL2 Protein, Mouse, Recombinant (His) MIP-2a,chemokine (C-X-C motif) ligand 2,Scyb,MIP-2,Gro	Mouse	P. pastoris (Yeast)
	GRO beta/CXCL2 Protein, Mouse, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 9.2 kDa and the accession number is P10889.
TMPY-02064	GRO beta/CXCL2 Protein, Mouse, Recombinant (His & SUMO) Mip2,GRO β/CXCL2,chemokine (C-X-C motif) l...	Mouse	E. coli
	GRO beta/CXCL2 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with His and SUMO tag. The predicted molecular weight is 21.2 kDa and the accession number is P10889-1.
TMPY-04703	GRO gama/CXCL3 Protein, Mouse, Recombinant (His) chemokine (C-X-C motif) ligand 3,GRO γ,Dcip1,Gm1960	Mouse	P. pastoris (Yeast)
	GRO gama/CXCL3 Protein, Mouse, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 9.3 kDa and the accession number is Q6W5C0.
TMPY-00899	GRO gama/CXCL3 Protein, Human, Recombinant (His) MIP-2b,MIP2B,CXCL3,SCYB3,GRO γ,CINC-2b,chemokine (C...	Human	E. coli
	GRO gama/CXCL3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 10.1 kDa and the accession number is P19876.

重组蛋白

GRO beta/CXCL2 Protein, Human, Recombinant

Cat.No: TMPY-00006

Species: Human

Expression System: E. coli

GRO beta/CXCL2 Protein, Rat, Recombinant

Cat.No: TMPY-00009

Species: Rat

Expression System: E. coli

CXCL2 Protein, Mouse, Recombinant

Cat.No: TMPJ-00011

Species: Mouse

Expression System: E. coli

GRO beta/CXCL2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04789

Species: Mouse

Expression System: P. pastoris (Yeast)

GRO beta/CXCL2 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPY-02064

Species: Mouse

Expression System: E. coli

GRO gama/CXCL3 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04703

Species: Mouse

Expression System: P. pastoris (Yeast)

GRO gama/CXCL3 Protein, Human, Recombinant (His)

Cat.No: TMPY-00899

Species: Human

Expression System: E. coli

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